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KMID : 0043320090320101369
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Archives of Pharmacal Research
2009 Volume.32 No. 10 p.1369 ~ p.1372
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A New ent-Kaurane type Diterpenoid Glycoside from Inula japonica Thunb.
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Jin Hui Zi
Zhu Jia Xian
Qin Jiang Jiang
Zhang Wei Dong
Zhu Yan
Fu Jian Jun
Liu Xiao-Hua
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Abstract
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A new ent-kaurane type diterpenoid glycoside, 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid (1), together with 17-hydroxy-16α-ent-kauran-19-oic acid (2), 16α,17-dihydroxyl-ent-kauran-19-oic acid (3), and 16α-hydroxy-17-acetoxy-ent- kauran-19-oic acid (4) were isolated from the aerial parts of Inula japonica Thunb. The structure of 1 was determined mainly by use of 1D and 2D NMR spectroscopic techniques including HSQC, 1H-1H COSY, HMBC, and NOESY. In addition, 4 exhibited significant inhibitory activity on NO production in LPS-stimulated RAW264.7 cells with IC50 value of 14.3 μg/mL.
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KEYWORD
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Inula japonica Thunb., 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid, NO production
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